Dimethylformamide dimethyl acetal → Methyl 4-(dimethylamino)-3-methyl-2-oxo-3-butenoate

HRID 895297Notes

Reaction equation

HRID 895297 reaction equation
[CH3:1][O:2][C:3](=[O:8])[C:4](=[O:7])[CH2:5][CH3:6].CO[CH:11](OC)[N:12]([CH3:14])[CH3:13]>>[CH3:1][O:2][C:3](=[O:8])[C:4](=[O:7])[C:5]([CH3:6])=[CH:11][N:12]([CH3:13])[CH3:14]

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 5451272-Ketobutyric acid methyl ester

Product 1

HCID 73885078Methyl 4-(dimethylamino)-3-methyl-2-oxo-3-butenoate

Procedure

Methyl-2-ketobutyrate (5 g, 43 mmol) was added at ambient temperature to dimethylformamide dimethyl acetal (5.13 g, 43 mmol, 5.72 ml). The solution was stirred overnight under nitrogen and then the volatile components were removed in vacuo at 40° C. The yellow residue was used without further purification.

Workup

  1. customthe volatile components were removed in vacuo at 40° C
  2. customThe yellow residue was used without further purification

Sources & evidence

ORD record
ord-d4f33b2d06764420811c3e9fbe0f2bbb
Source dataset
uspto-grants-2005_07
Patent number
US06914160B1

Reaction notes

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