tert-Butoxy bis(dimethylamino)methane → HCID 69219756, compound

HRID 895356Notes

Reaction equation

HRID 895356 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH2:14][C:15](=[O:18])[NH:16][N:17]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].C(O[CH:24](N(C)C)[N:25]([CH3:27])[CH3:26])(C)(C)C>C(#N)C>[CH3:24][N:25]([CH:27]=[C:14]1[C:13]([C:5]2[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=2)=[N:17][NH:16][C:15]1=[O:18])[CH3:26]

Participants

4

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 22353179HCID 22353179, compound

Product 1

HCID 69219756HCID 69219756, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Conditions

Temperature
35 °C

Procedure

5-(3,4,5-Trimethoxyphenyl)-2,4-dihydro-pyrazol-3-one (k, 2 g) in dry actonitrile (10 mL) was added C-tert-Butoxy-N,N,N′,N′-tetramethyl-methanediamine (3 mL) and stirred at 35° C. The reaction was monitored by HPLC. After 36 hours, the solid was filtered and rinsed with dry acetonitrile (5 mL) and dried under nitrogen pressure to yield the title compound (1).

Workup

  1. filtrationthe solid was filtered
  2. washrinsed with dry acetonitrile (5 mL)
  3. customdried under nitrogen pressure

Sources & evidence

ORD record
ord-d8b6203e262f447c99ff3e29c4b90476
Source dataset
uspto-grants-2005_07
Patent number
US06916798B2

Reaction notes

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