Formamide → HCID 22379597, compound

Temperature

60 °C

1-(2-Fluoro-phenyl)-ethanone (2.24 g, 16.23 mmol) and formamide (3.9 mL 97.4 mmol) were added to a flame-dried flask, stirred, and heated to 60° C. Bromine (832 μL, 16.23 mmol) was added dropwise. Upon completion of the bromine addition, the reaction was stirred for 30 minutes, and then the temperature was increased to 125° C. After 3.5 hour further stirring, the reaction mixture was cooled and diluted with 100 mL water. 1N sodium hydroxide was added to increase the pH to about 10. The aqueous layer was extracted twice with diethylether, the combined ether layers were washed with water, dried with magnesium sulfate and concentrated under vacuum. The crude material obtained was chromatographed on silica gel (ISCO MPLC purification, 40 minutes, 0-50% ethyl acetate gradient, Biotage flash 40 m column) to provide 580 mg (22%) of the title compound. 1H NMR (400 MHz, CD3OD) δ 8.26 (s, 1H), 8.22 (d, 1H, J=9.9 Hz), 8.0 (m, 1H), 7.3 (m, 3H).

1. stirringthe reaction was stirred for 30 minutes
2. temperaturethe temperature was increased to 125° C
3. stirringAfter 3.5 hour further stirring
4. temperaturethe reaction mixture was cooled
5. temperatureto increase the pH to about 10
6. extractionThe aqueous layer was extracted twice with diethylether
7. washthe combined ether layers were washed with water
8. dry with materialdried with magnesium sulfate
9. concentrationconcentrated under vacuum
10. customThe crude material obtained
11. customwas chromatographed on silica gel (ISCO MPLC purification, 40 minutes, 0-50% ethyl acetate gradient, Biotage flash 40 m column)

ORD record

ord-917481c7647b42828224d476e78064cb

Source dataset

uspto-grants-2005_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06916807B2