反应详情

A mixture of 4-(4-fluorophenyl)-1-[2-(1-t-butoxycarbonylpiperidin-4-yl)-ethenylsulphonyl]-piperazine (1.96 g) and trifluoroacetic acid (5 ml) was stirred at ambient temperature for 5 hours. The mixture was evaporated to dryness, diluted with water, basified with aqueous 2M sodium hydroxide and extracted with ethyl acetate (2×20 ml). Removal of the solvent gave 4-(4-fluorophenyl)-1-[2-(piperidin-4-yl)-ethenylsulphonyl]-piperazine.

1. customThe mixture was evaporated to dryness
2. additiondiluted with water
3. extractionextracted with ethyl acetate (2×20 ml)
4. customRemoval of the solvent