4-Azaindole → HCID 9881228, compound

HRID 895408Notes

Reaction equation

HRID 895408 reaction equation
[NH:1]1[C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[NH:10]1[CH2:14][CH2:13][CH2:12][CH2:11]1>C(O)C>[CH2:13]1[CH:14]2[N:10]([CH2:2][CH:3]=[C:4]([C:3]3[C:4]4[C:9](=[CH:8][CH:7]=[CH:6][N:5]=4)[NH:1][CH:2]=3)[CH2:9]2)[CH2:11][CH2:12]1

Participants

4

Reactant 2

HCID 92264-AzaindoleHCID 31268Pyrrolidine

Product 1

HCID 9881228HCID 9881228, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

from 4-azaindole (1.0 g, 8.46 mmol), 1,2,3,5,6,8,8a-heptahydrohydro-7-oxo-indolizine (1.77 g, 12.7 mmol) and pyrrolidine (3.5 g, 42.3 mmol) in ethanol (8 mL), heating at reflux for 3 hrs.

Workup

  1. temperatureat reflux for 3 hrs

Sources & evidence

ORD record
ord-e6cc02c9ba4245aeafa2017dbbe27948
Source dataset
uspto-grants-2005_07
Patent number
US06916818B2

Reaction notes

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