反应详情

温度

130 °C

N-(6-Chloro-2-phenylpyrimidin-4-yl)-2-piperidin-1-ylacetamide (25 mg) was dissolved in DMSO (1 ml) and N-acetylethylenediamine (78 mg) added. A reflux condenser was fitted and the mixture heated to 130° C. with stirring for 16 hrs. The reaction was cooled to room temperature and the solvent removed in vacuo. Purification via flash chromatography on silica gel, eluting with a mixture of dichloromethane and methanol (95:5, then 93:7 v/v) yielded the title compound (18 mg).

1. customA reflux condenser was fitted
2. temperatureThe reaction was cooled to room temperature
3. customthe solvent removed in vacuo
4. customPurification via flash chromatography on silica gel
5. washeluting with a mixture of dichloromethane and methanol (95:5