HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 895479Generated: October 26, 2026
N-(2-aminoethyl)acetamide → N-(6-{[2-(acetylamino)ethyl]amino)-2-phenylpyrimidin-4-yl)-2-piperidin-1-ylacetamide
https://huagongshe.com/reaction/895479
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | N-(2-aminoethyl)acetamide | HCID 66082 | — |
| Reactant | N-(6-chloro-2-phenylpyrimidin-4-yl)-2-piperidin-1-ylacetamide | HCID 22353518 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | N-(6-{[2-(acetylamino)ethyl]amino)-2-phenylpyrimidin-4-yl)-2-piperidin-1-ylacetamide | HCID 22379308 | 60.1% |
Reaction Steps
N-(6-Chloro-2-phenylpyrimidin-4-yl)-2-piperidin-1-ylacetamide (25 mg) was dissolved in DMSO (1 ml) and N-acetylethylenediamine (78 mg) added. A reflux condenser was fitted and the mixture heated to 130° C. with stirring for 16 hrs. The reaction was cooled to room temperature and the solvent removed in vacuo. Purification via flash chromatography on silica gel, eluting with a mixture of dichloromethane and methanol (95:5, then 93:7 v/v) yielded the title compound (18 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06916804B2 |
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| Source dataset | uspto-grants-2005_07 |
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| ORD ID | ord-d3827df11eb24749926ae2b3eacd5208 |
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| Source note | uspto-grants-2005_07 |
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