HCID 20811457, compound → HCID 22353453, compound

HRID 895483Notes

Reaction equation

HRID 895483 reaction equation
[C:1]([NH:4][CH2:5][CH2:6][NH:7][C:8]1[N:13]=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:11]=[C:10]([NH:20][C:21](=[O:26])[C:22]([O:24]C)=[O:23])[CH:9]=1)(=[O:3])[CH3:2]>C1COCC1>[C:1]([NH:4][CH2:5][CH2:6][NH:7][C:8]1[N:13]=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[N:11]=[C:10]([NH:20][C:21](=[O:26])[C:22]([OH:24])=[O:23])[CH:9]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 20811457HCID 20811457, compound

Product 1

HCID 22353453HCID 22353453, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Methyl [(6-{[2-(acetylamino)ethyl]amino}-2-phenylpyrimidin-4-yl)amino](oxo)acetate (10 mg) was dissolved in anhydrous THF (1.5 ml) and potassium trimethylsilanate (4 mg) added. The reaction was left for 3 hrs after which time a precipitate of the title compound was visible which was filtered (10 mg).

Sources & evidence

ORD record
ord-6ae21e291a45443c8f6a432d15057389
Source dataset
uspto-grants-2005_07
Patent number
US06916804B2

Reaction notes

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