Sodium Acetate → HCID 73884807, compound

HRID 895522Notes

Reaction equation

HRID 895522 reaction equation
[CH2:1]([N:3]1[C:7]2[CH:8]=[CH:9][C:10]([C:12](=O)[CH3:13])=[CH:11][C:6]=2[N:5]=[C:4]1[CH2:15][C:16]1[N:17]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[CH:22]=2)[N:18]=[CH:19][CH:20]=1)[CH3:2].Cl.[O:29]([NH2:31])[CH3:30].C([O-])(=O)C.[Na+]>CO>[CH2:1]([N:3]1[C:7]2[CH:8]=[CH:9][C:10]([C:12](=[N:31][O:29][CH3:30])[CH3:13])=[CH:11][C:6]=2[N:5]=[C:4]1[CH2:15][C:16]1[N:17]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[CH:22]=2)[N:18]=[CH:19][CH:20]=1)[CH3:2]

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 521874O-Methylhydroxylamine hydrochlorideHCID 22380334HCID 22380334, compound

Product 1

HCID 73884807HCID 73884807, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 1-Ethyl-2-{[2-(3-fluorophenyl)-pyrazol-3-yl]methyl}-5-acetyl-1H-benzimidazole (23 mg), methoxylamine hydrochloride (15 mg, 3 eq.), and sodium acetate (15 mg, 3 eq.) in methanol (1 mL) is stirred at room temperature overnight. The solvent is removed in vacuo and aqueous sodium bicarbonate added to pH 9, then extracted with ethyl acetate. The organic layer is dried (Na2SO4) and concentrated to give 1-Ethyl-2-{[2-(3-fluorophenyl)-pyrazol-3-yl]methyl}-5-[1-(methoxyimino)ethyl]-1H-benzimidazole. 1H NMR (CDCl3): δ 7.94 (d, 1H); 7.73 (dd, 1H); 7.73 (dd, 1H); 7.63 (d, 1H); 7.52 (m, 1H); 7.38-7.40 (m, 3H); 7.27 (m, 1H); 6.19 (d, 1H); 4.32 (s, 2H); 3.87-4.10 (m, 5H); 2.30 (s, 3H); 1.22 (t, 3H).

Workup

  1. customThe solvent is removed in vacuo and aqueous sodium bicarbonate
  2. additionadded to pH 9
  3. extractionextracted with ethyl acetate
  4. dry with materialThe organic layer is dried (Na2SO4)
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-5500e10f85b348aeaf8264e46d2d5906
Source dataset
uspto-grants-2005_07
Patent number
US06916819B2

Reaction notes

Loading…