HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Dichloroethane → 8-Chloromethyl-2,9-dimethyl-9H-purine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Dichloroethane | HCID 6365 | — |
| Reactant | Ethyl 2-chloroethanecarboximidate hydrochloride | HCID 12470659 | — |
| Reactant | HCID 22380283 | HCID 22380283 | — |
| Product | 8-Chloromethyl-2,9-dimethyl-9H-purine | HCID 22379955 | — |
Reaction Steps
A solution of 2,N-Dimethyl-4,5-diaminopyrimidine (180 mg, 1.3 mmol) and ethyl chloroacetimidate hydrochloride (310 g, 2.0 mmol) in dichloroethane (10 mL) is heated at reflux for 17 h and cooled. The mixture is washed with aqueous NaHCO3, water, dried and concentrated to give 8-Chloromethyl-2,9-dimethyl-9H-purine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06916819B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-35f4e5f9a40543efb87299fdf778eb5e |
| Source note | uspto-grants-2005_07 |