Trifluoroacetic acid → 3-Benzyl-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one Trifluoroacetate

HRID 895616Notes

Reaction equation

HRID 895616 reaction equation
[CH2:1]([N:8]1[C:12](=[O:13])[C:11]2([CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]2)[N:10]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35]>>[F:32][C:33]([F:38])([F:37])[C:34]([OH:36])=[O:35].[CH2:1]([N:8]1[C:12](=[O:13])[C:11]2([CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[N:10]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 6422Trifluoroacetic acidHCID 223806103-Benzyl-8-(tert-butoxycarbonyl)-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one

Product 1

HCID 223805543-Benzyl-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one TrifluoroacetateYield 91%

Procedure

3-Benzyl-8-(tert-butoxycarbonyl)-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one (1.671 g) was added with trifluoroacetic acid (32 ml) with ice cooling and stirred at the same temperature for 1 hour. The solvent was evaporated under reduced pressure and then the residue was added with diisopropyl ether (50 ml) to precipitate the product. The precipitates was collected by filtration and dried to obtain 1.561 g of the title compound. Yield: 91%.

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. additionthe residue was added with diisopropyl ether (50 ml)
  3. customto precipitate the product
  4. filtrationThe precipitates was collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-1a816c0197b24b25bbccd89309b367d5
Source dataset
uspto-grants-2005_07
Patent number
US06916822B2

Reaction notes

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