4-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride → 4-Phenylpiperidinium chloride

HRID 895626Notes

Reaction equation

HRID 895626 reaction equation
[ClH:1].[C:2]1([C:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH:13]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CO.[Pd]>[ClH:1].[C:2]1([CH:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 1

HCID 27238604-Phenyl-1,2,3,6-tetrahydropyridine hydrochloride

Product 1

HCID 825094-Phenylpiperidinium chlorideYield 99%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Conditions

Temperature
45 °C

Procedure

1,2,3,6-Tetrahydro-4-phenylpyridine hydrochloride (70 mg) was dissolved in methanol (1.4 ml), added with 10% palladium/carbon (35 mg) and stirred at 45° C. for 5 hours under hydrogen gas atmosphere. After insoluble matters were removed by filtration, the solvent was evaporated under reduced pressure to obtain 70.0 mg of the title compound. Yield: 99%.

Workup

  1. customAfter insoluble matters were removed by filtration
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-07a5ec0616424cb3a181b522793b23b8
Source dataset
uspto-grants-2005_07
Patent number
US06916822B2

Reaction notes

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