Hydrogen Bromide → HCID 22380690, compound

HRID 895637Notes

Reaction equation

HRID 895637 reaction equation
C(OC([N:6]1[CH2:11][CH2:10][CH:9]([N:12]2[C:16]3[C:17]([CH3:21])=[CH:18][CH:19]=[CH:20][C:15]=3[NH:14][C:13]2=[O:22])[CH2:8][CH2:7]1)=O)C.C(O)C.[BrH:26]>>[BrH:26].[CH3:21][C:17]1[C:16]2[N:12]([CH:9]3[CH2:10][CH2:11][NH:6][CH2:7][CH2:8]3)[C:13](=[O:22])[NH:14][C:15]=2[CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 702EthanolHCID 22380577HCID 22380577, compound

Product 1

HCID 22380690HCID 22380690, compoundYield 44%

Conditions

Temperature
100 °C

Procedure

1-Ethoxycarbonyl-4-(1,3-dihydro-7-methyl-2H-benzimidazol-2-on-1-yl)piperidine (59 mg) was dissolved in 48% hydrobromic acid (0.3 ml) and stirred at 100° C. for 1 hour. The reaction mixture was added with ethanol, and the produced crystals were collected by filtration to obtain 26.8 mg of the title compound. Yield: 44%.

Workup

  1. filtrationthe produced crystals were collected by filtration

Sources & evidence

ORD record
ord-8e7a5cf917454f7a9ac48b2b49077907
Source dataset
uspto-grants-2005_07
Patent number
US06916822B2

Reaction notes

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