4-N-ethylpyridine-3,4-diamine → 1-ethyl-2-(2-thiazol-2-yl-imidazol-1-ylmethyl)-1H-imidazo[4,5-c]pyridine
Reaction equation
[CH2:1]([NH:3][C:4]1[CH:9]=[CH:8][N:7]=[CH:6][C:5]=1[NH2:10])[CH3:2].CO[C:13](=O)[CH2:14][N:15]1[CH:19]=[CH:18][N:17]=[C:16]1[C:20]1[S:21][CH:22]=[CH:23][N:24]=1>>[CH2:1]([N:3]1[C:4]2[CH:9]=[CH:8][N:7]=[CH:6][C:5]=2[N:10]=[C:13]1[CH2:14][N:15]1[CH:19]=[CH:18][N:17]=[C:16]1[C:20]1[S:21][CH:22]=[CH:23][N:24]=1)[CH3:2]Participants
3
Procedure
The title compound is prepared from N4-ethyl-pyridine-3,4-diamine and (2-thiazol-2-yl-imidazol-1-yl)-acetic acid methyl ester following the procedure given in Example 8. 1H NMR (CDCl3) δ 9.08 (s, 1 H), 8.43 (d, 1 H), 7.85 (d, 1 H), 7.38 (d, 1 H), 7.38-7.26 (m, 1 H), 7.17 (s, 1 H), 7.14 (s, 1 H), 6.35 (s, 2 H), 4.25 (q, 2 H), 1.11 (t, 3 H). Electrospray MS: m/z 311 [M+1]
Sources & evidence
- ORD record
- ord-e193dd037c34465a9939b51b3c07234f
- Source dataset
- uspto-grants-2005_07
- Patent number
- US06916827B2
Reaction notes
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