Hydroxyamine hydrochloride → HCID 86759748, compound

HRID 895707Notes

Reaction equation

[NH2:1][CH:2]([CH2:6][CH2:7][C:8](=[O:30])[NH:9][CH:10]([C:23](=[O:29])[NH:24][CH2:25][C:26]([OH:28])=[O:27])[CH2:11][S:12][CH2:13][C:14]([C:16]([O:18][CH2:19][CH2:20]CC)=[O:17])=O)[C:3]([OH:5])=[O:4].Cl.[NH2:32][OH:33]>>[NH2:1][CH:2]([CH2:6][CH2:7][C:8](=[O:30])[NH:9][CH:10]([C:23](=[O:29])[NH:24][CH2:25][C:26]([OH:28])=[O:27])[CH2:11][S:12][CH2:13][C:14]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[N:32][OH:33])[C:3]([OH:5])=[O:4]

Participants

Reactant 2

HCID 443297Hydroxyamine hydrochloride

HCID 86759749HCID 86759749, compound

Product 1

HCID 86759748HCID 86759748, compound

Procedure

Similarly, by following the procedure of Example 30A and substituting 2-amino-4-[1-(carboxymethyl-carbamoyl)-2-(2-ethoxycarbonyl-2-oxo-ethylsulfanyl)-ethylcarbamoyl]-butyric acid with 2-amino-4-[2-(2-butoxycarbonyl-2-oxo-ethylsulfanyl)-1-(carboxymethyl-carbamoyl)-ethylcarbamoyl]-butyric acid and hydroxylamine HCl with another substituted hydroxylamine there are obtained the following compounds:

Workup

customare obtained the following compounds

Sources & evidence

ORD record: ord-ec8923edb6754ca88b3b84d6451bedc6
Source dataset: uspto-grants-2005_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06916850B2

Reaction notes

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