反应详情

A mixture of 3-bromo-1H-2-pyridone (740 mg, 4.25 mmol), potassium carbonate (1.18 g, 8.5 mmol) and iodomethane (2.65 mL, 42.5 mmol) in DME (10 mL) was heated to reflux overnight. The mixture was filtered, washing with ethyl acetate and the filtrate was evaporated to dryness. The residue was purified by dry column chromatography over 27 g of silica gel, eluting with ethyl acetate to give 3-bromo-1-methyl-2-pyridone (0.63 g, 79%). LRMS (electrospray), positive ion, 188 (M+H).

1. temperaturewas heated
2. temperatureto reflux overnight
3. filtrationThe mixture was filtered
4. washwashing with ethyl acetate
5. customthe filtrate was evaporated to dryness
6. customThe residue was purified
7. customby dry column chromatography over 27 g of silica gel
8. washeluting with ethyl acetate