Water → 2-chloro-N-(2-hydroxyphenyl)-5-nitrobenzamide

HRID 895972Notes

Reaction equation

HRID 895972 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4](Cl)=[O:5].[NH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[OH:21].C(=O)(O)[O-].[Na+].O>C(OCC)C>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][C:3]=1[C:4]([NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[OH:21])=[O:5]

Participants

6

Reactant 4

HCID 962WaterHCID 58012-AminophenolHCID 117637Benzoyl chloride, 2-chloro-5-nitro-HCID 516892Sodium Bicarbonate

Product 1

HCID 43061272-chloro-N-(2-hydroxyphenyl)-5-nitrobenzamide

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

2-Chloro-5-nitro-benzoyl chloride in 60 mL of diethyl ether was added to an ice-cooled mixture of o-aminophenol (5.4 g) and sodium bicarbonate (8.3 g), water (36 mL) and ether (20 mL) over a period of 1 hour. The mixture was allowed to warm to room temperature and stirred overnight. The precipitate was filtered and washed sequentially with water (3×100 mL), 2N HCl (3×100 mL) and diethyl ether (3×50 mL). Yield 11.2 g (77%).

Workup

  1. temperaturecooled
  2. filtrationThe precipitate was filtered
  3. washwashed sequentially with water (3×100 mL), 2N HCl (3×100 mL) and diethyl ether (3×50 mL)

Sources & evidence

ORD record
ord-80fb053a761a4697b85357a75a6c2b97
Source dataset
uspto-grants-2005_07
Patent number
US06919328B1

Reaction notes

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