5-Bromo-2-furanecarboxylic acid → HCID 9943685, compound

HRID 895995Notes

Reaction equation

HRID 895995 reaction equation
[Br:1][C:2]1[O:6][C:5]([C:7]([OH:9])=O)=[CH:4][CH:3]=1.[NH2:10][CH2:11][P:12](=[O:19])([O:16]CC)[O:13]CC.C[Si](Br)(C)C>>[P:12]([CH2:11][NH:10][C:7]([C:5]1[O:6][C:2]([Br:1])=[CH:3][CH:4]=1)=[O:9])([OH:19])([OH:16])=[O:13]

Participants

4

Reactant 3

HCID 685115-Bromo-2-furanecarboxylic acidHCID 76113BromotrimethylsilaneHCID 1596920Diethyl (aminomethyl)phosphonate

Product 1

HCID 9943685HCID 9943685, compound

Procedure

5-Bromofuroic acid was reacted with diethyl aminomethylphosphonate in a manner similar to that described in Step D, Example 5. The product was treated with TMSBr as described in Step D, Example 1 to provide the title compound (no. 8.01) as a solid. HPLC Rt=3.72 min; negative ion electrospray MS M−1 found: 282/284.

Sources & evidence

ORD record
ord-700535a5e5684ba289472c5d1478e5cb
Source dataset
uspto-grants-2005_07
Patent number
US06919322B2

Reaction notes

Loading…