Ethanol → 6,8-Dibromoimidazo[1,2-a]pyrazine

HRID 896076Notes

Reaction equation

HRID 896076 reaction equation
[Br:1][C:2]1[C:3]([NH2:9])=[N:4][CH:5]=[C:6]([Br:8])[N:7]=1.[CH2:10](O)[CH3:11]>>[Br:8][C:6]1[N:7]=[C:2]([Br:1])[C:3]2[N:4]([CH:10]=[CH:11][N:9]=2)[CH:5]=1

Participants

3

Reactant 2

HCID 702EthanolHCID 6200042-Amino-3,5-dibromopyrazine

Product 1

HCID 150258436,8-Dibromoimidazo[1,2-a]pyrazine

Procedure

A solution of 1.00 equivalents (eq.) of 3,5-dibromo-2-aminopyrazine 1 in ethanol is treated with 2.00 eq. of α-bromoaldehyde 2 at room temperature (RT) and heated for 48 hours (hr). The solvent is removed under reduced pressure and the residue is triturated with diethyl ether and filtered to give the HBr salt 3.

Workup

  1. temperatureheated for 48 hours (hr)
  2. customThe solvent is removed under reduced pressure
  3. customthe residue is triturated with diethyl ether
  4. filtrationfiltered

Sources & evidence

ORD record
ord-0787d25f1e61467194acbab7800f10ec
Source dataset
uspto-grants-2005_07
Patent number
US06919340B2

Reaction notes

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