HRID896086

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCC[CH2][Sn]([CH2]CCC)([CH2]CCC)[c]1ccnc(SC)n1

HCID2763261

2-(Methylthio)-4-(tributylstannyl)pyrimidine

C17H32N2SSn

结构：COc1ccc(Br)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)nc1

HCID22349594

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(-c2ccnc(SC)n2)cc1C(=O)c1ccc(Nc2ccc(F)cc2F)nc1

HCID22349580

未命名化合物

收率 45%

PROCEDURE

实验过程

[6-(2,4-Difluoro-phenylamino)-pyridin-3-yl]-[2-methoxy-5-(2-methylsulfanyl-pyrimidin-4-yl)-phenyl]-methanone is prepared in analogy to example 11 from (5-bromo-2-methoxy-phenyl)-[6-(2,4-difluoro-phenylamino)-pyridin-3-yl]-methanone and 2-methylsulfanyl-4-tributylstannanyl-pyrimidine in 45% yield: