HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Methylthio)-4-(tributylstannyl)pyrimidine → [6-(2,4-Difluoro-phenylamino)-pyridin-3-yl]-[2-methoxy-5-(2-methylsulfanyl-pyrimidin-4-yl)-phenyl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Methylthio)-4-(tributylstannyl)pyrimidine | HCID 2763261 | — |
| Reactant | (5-Bromo-2-methoxy-phenyl)-[6-(2,4-difluoro-phenylamino)-pyridin-3-yl]-methanone | HCID 22349594 | — |
| Product | [6-(2,4-Difluoro-phenylamino)-pyridin-3-yl]-[2-methoxy-5-(2-methylsulfanyl-pyrimidin-4-yl)-phenyl]-methanone | HCID 22349580 | 45% |
Reaction Steps
[6-(2,4-Difluoro-phenylamino)-pyridin-3-yl]-[2-methoxy-5-(2-methylsulfanyl-pyrimidin-4-yl)-phenyl]-methanone is prepared in analogy to example 11 from (5-bromo-2-methoxy-phenyl)-[6-(2,4-difluoro-phenylamino)-pyridin-3-yl]-methanone and 2-methylsulfanyl-4-tributylstannanyl-pyrimidine in 45% yield:
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06919336B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-1eebe55b109b43398c3ca6b4e770e79f |
| Source note | uspto-grants-2005_07 |