反应详情

温度

78 °C

6.3 g of piperazine (73.5 mmol) were dissolved in 50 ml of ethanol. 2.31 g of 2-tert-butyl-4-chloro-6-difluoromethyl-pyrimidine (10.5 mmol) were added and the mixture was stirred for 3 h at 78° C. The solvent was evaporated and the residue was added slowly to 100 ml of water. After cooling, the pH was adjusted to 12 with 2 N aqueous sodium hydroxide, and aqueos layer was extracted with dichloromethane. The organic layer was dried over magnesium sulfate, filtered and the solvent was evaporated to yield 2.34 g of the title compound.

1. customThe solvent was evaporated
2. additionthe residue was added slowly to 100 ml of water
3. temperatureAfter cooling
4. extractionwas extracted with dichloromethane
5. dry with materialThe organic layer was dried over magnesium sulfate
6. filtrationfiltered
7. customthe solvent was evaporated