2-(4-Fluorophenyl)-3-hydroxy-3-pyridin-4-yl-propionic acid methyl ester → 2-(4-Fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-3-oxo-propionic acid methyl ester

HRID 896230Notes

Reaction equation

HRID 896230 reaction equation
[CH3:1][O:2][C:3](=[O:22])[CH:4]([C:15]1[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=1)[CH:5]([OH:14])[C:6]1[CH:11]=[CH:10][N:9]=[C:8]([S:12][CH3:13])[N:7]=1.COC(=O)C(C1C=CC(F)=CC=1)C(O)C1C=CN=CC=1>>[CH3:1][O:2][C:3](=[O:22])[CH:4]([C:15]1[CH:16]=[CH:17][C:18]([F:21])=[CH:19][CH:20]=1)[C:5](=[O:14])[C:6]1[CH:11]=[CH:10][N:9]=[C:8]([S:12][CH3:13])[N:7]=1

Participants

3

Reactant 2

HCID 121505362-(4-Fluorophenyl)-3-hydroxy-3-pyridin-4-yl-propionic acid methyl esterHCID 129914022-(4-Fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-3-hydroxypropionic acid methyl ester

Product 1

HCID 129914032-(4-Fluorophenyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-3-oxo-propionic acid methyl ester

Procedure

Using the procedure from Example 1b set forth above, substitute 2-(4-fluorophenyl)-3-hydroxy-3-(2-methylsulfanyl-pyrimidin-4-yl)-propionic acid methyl ester for 2-(4-fluorophenyl)-3-hydroxy-3-pyridin-4-yl-propionic acid methyl ester to produce the title compound.

Sources & evidence

ORD record
ord-350b1ad44b624ecb82efcddfc8c07708
Source dataset
uspto-grants-2005_07
Patent number
US06919346B2

Reaction notes

Loading…