反应详情

To a stirred solution of 2-choro-4-cyanobenzyl bromide (6.9 g, 30.0 mmol) in DMF (150 ml), was added sodium azide (2.0 g, 30 mmol) The reaction was stirred overnight at room temperature, and then filtered. The DMF was removed from filtrate in vacuo. The residue was dissolved in EtOAc (300 ml), washed with water (200 ml×3), brine (200 ml×1), dried over sodium sulfate. Removed solvent in vacuo to give 5.8 g of raw 2-choro-4-cyanobenzyl azide.

1. filtrationfiltered
2. customThe DMF was removed from filtrate in vacuo
3. dissolutionThe residue was dissolved in EtOAc (300 ml)
4. washwashed with water (200 ml×3), brine (200 ml×1)
5. dry with materialdried over sodium sulfate