1-(2,3-Dihydroimidazo[2,1-b][1,3]thiazol-6-yl)methanamine → 6-({[(8-Hydroxy-1,6-naphthyridin-7-yl)carbonyl]amino}methyl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole

HRID 896284Notes

Reaction equation

HRID 896284 reaction equation
F[C:2](F)(F)[C:3]([O-:5])=O.S1[C:12]2=N[CH:14]=[NH+:15][C:11]2=NC1.[OH2:16].[Cl-].[Cl-].[NH3+]CC1[NH2+][C:24]2[CH:26]=[CH:27]C=C[C:23]=2[N:22]=1.[S:30]1[CH2:34][CH2:33][N:32]2[CH:35]=[C:36]([CH2:38][NH2:39])[N:37]=[C:31]12>>[OH:5][C:3]1[C:11]([C:12]([NH:39][CH2:38][C:36]2[N:37]=[C:31]3[N:32]([CH:35]=2)[CH2:33][CH2:34][S:30]3)=[O:16])=[N:15][CH:14]=[C:27]2[C:2]=1[N:22]=[CH:23][CH:24]=[CH:26]2

Participants

4

Reactant 3

HCID 70618911-(2,3-Dihydroimidazo[2,1-b][1,3]thiazol-6-yl)methanamineHCID 43835646Benzimidazol-2-ylmethylamine, oxamethane, chloride, chlorideHCID 178420910HCID 178420910, compound

Product 1

HCID 98585806-({[(8-Hydroxy-1,6-naphthyridin-7-yl)carbonyl]amino}methyl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole

Procedure

The title compound was prepared as the imidazothiazol-4-ium trifluoroacetate salt using the procedure described in Example 1, Step 4 replacing 2-(ammoniomethyl)-1H-benzimidazol-1-ium dichloride hydrate with 1-(2,3-dihydroimidazo[2,1-b][1,3]thiazol-6-yl)methanamine.

Sources & evidence

ORD record
ord-1416935972c34105b615310d48bed2d3
Source dataset
uspto-grants-2005_07
Patent number
US06919351B2

Reaction notes

Loading…