Ammonium Hydroxide → 2-(3-Isopropyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazole-5-carboxylic acid amide

HRID 896305Notes

Reaction equation

C[N:2](C)[C:3]([C:5]1[CH:32]=[CH:31][C:8]2[N:9]([CH2:26][CH2:27][CH:28]([CH3:30])[CH3:29])[C:10]([CH2:12][N:13]3[C:17]4[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=4[N:15]([CH:22]([CH3:24])[CH3:23])[C:14]3=[O:25])=[N:11][C:7]=2[CH:6]=1)=[O:4].[OH-].[NH4+]>>[CH:22]([N:15]1[C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[N:13]([CH2:12][C:10]2[N:9]([CH2:26][CH2:27][CH:28]([CH3:30])[CH3:29])[C:8]3[CH:31]=[CH:32][C:5]([C:3]([NH2:2])=[O:4])=[CH:6][C:7]=3[N:11]=2)[C:14]1=[O:25])([CH3:23])[CH3:24]

Participants

Reactant 2

HCID 14923Ammonium Hydroxide

HCID 208140222-(3-isopropyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazole-5-carboxylic acid dimethylamide

Product 1

HCID 208140212-(3-Isopropyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazole-5-carboxylic acid amide

Procedure

2-(3-Isopropyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazole-5-carboxylic acid amide was prepared by the same procedure as 2-(3-isopropyl-2-oxo-2,3-dihydro-benzoimidazol-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazole-5-carboxylic acid dimethylamide, except using ammonium hydroxide.

Sources & evidence

ORD record: ord-9e232038b2ea4344afeced2b2de16c6e
Source dataset: uspto-grants-2005_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06919331B2

Reaction notes

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