Cyclopropylamine → N-Cyclopropyl-3-nitropyridin-4-amine

HRID 896338Notes

Reaction equation

HRID 896338 reaction equation
CO[C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[N+:9]([O-:11])=[O:10].[CH:12]1([NH2:15])[CH2:14][CH2:13]1>CCO>[CH:12]1([NH:15][C:3]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[N+:9]([O-:11])=[O:10])[CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 69828CyclopropylamineHCID 3558324-Methoxy-3-nitropyridine

Product 1

HCID 22349359N-Cyclopropyl-3-nitropyridin-4-amine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4-methoxy-3-nitropyridine (7.71 g, 50 mmol) and cyclopropylamine (7.14 g, 125 mmol) in EtOH (20 mL) was heated at 80° C. in a sealed tube for 2 h. The solvent was evaporated to give cyclopropyl-(3-nitro-pyridin-4-yl)-amine as a yellow solid.

Workup

  1. customThe solvent was evaporated

Sources & evidence

ORD record
ord-942d2294fd7f41c6ae865d9f689aecfc
Source dataset
uspto-grants-2005_07
Patent number
US06919331B2

Reaction notes

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