反应详情

温度

0 °C

To a cooled (0° C.) solution of [2-hydroxymethyl-1-(3-methyl-butyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester (146 mg, 0.42 mmol) in DCM (5 mL) was added thionyl chloride (46 μL, 0.63 mmol). The solution was stirred at 0° C. for 15 min. and concentrated in vacuo to give [2-chloromethyl-1-(3-methyl-butyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester; HCl salt (176 mg, 100%) as a white solid, which was used without further purification.

1. concentrationconcentrated in vacuo