HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 896341Generated: October 29, 2026
Thionyl Chloride → HCID 59561810, compound
https://huagongshe.com/reaction/896341
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | tert-Butyl N-[[2-(hydroxymethyl)-1-isopentyl-benzimidazol-5-yl]methyl]-carbamate | HCID 59561849 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 59561810 | HCID 59561810 | — |
Reaction Steps
To a cooled (0° C.) solution of [2-hydroxymethyl-1-(3-methyl-butyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester (146 mg, 0.42 mmol) in DCM (5 mL) was added thionyl chloride (46 μL, 0.63 mmol). The solution was stirred at 0° C. for 15 min. and concentrated in vacuo to give [2-chloromethyl-1-(3-methyl-butyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester; HCl salt (176 mg, 100%) as a white solid, which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06919331B2 |
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| Source dataset | uspto-grants-2005_07 |
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| ORD ID | ord-b2c49bbd95524e73ad2d24378976c321 |
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| Source note | uspto-grants-2005_07 |
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