反应详情

The procedure for the preparation of [2-(3-cyclopropyl-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazol-5-ylmethyl]-carbamic acid tert-butyl ester was followed starting from 3-cyclopropyl-1H-quinazoline-2,4-dione (309 mg, 1.53 mmol) and 2-chloromethyl-1-(3-methyl-butyl)-1H-benzoimidazole-5-carboxylic acid methyl ester; HCl salt (506 mg, 1.53 mmol). At the end of the reaction a precipitate had formed. The mixture was diluted with water, and the solid collected by filtration. After washing with water and diethyl ether and drying in vacuo, 2-(3-Cyclopropyl-2,4-dioxo-3,4-dihydro-2H-quinazolin-1-ylmethyl)-1-(3-methyl-butyl)-1H-benzoimidazole-5-carboxylic acid methyl ester (634 mg, 90%) was obtained as a white solid:

1. customAt the end of the reaction a precipitate
2. customhad formed
3. filtrationthe solid collected by filtration
4. washAfter washing with water and diethyl ether
5. customdrying in vacuo