HCID 22351066, compound → HCID 22351084, compound

HRID 896492Notes

Reaction equation

HRID 896492 reaction equation
[Cl:1][C:2]1[CH:38]=[CH:37][CH:36]=[CH:35][C:3]=1[C:4]([C:6]1[CH:34]=[CH:33][C:9]2[N:10]([CH2:14][CH2:15][O:16][C:17]3[CH:32]=[CH:31][C:20]([CH:21]=[C:22]([C:27]([O:29][CH3:30])=[O:28])[C:23]([O:25][CH3:26])=[O:24])=[CH:19][CH:18]=3)[C:11](=[O:13])[S:12][C:8]=2[CH:7]=1)=[O:5]>CO.C1COCC1.O1CCOCC1.[Pd]>[Cl:1][C:2]1[CH:38]=[CH:37][CH:36]=[CH:35][C:3]=1[C:4]([C:6]1[CH:34]=[CH:33][C:9]2[N:10]([CH2:14][CH2:15][O:16][C:17]3[CH:18]=[CH:19][C:20]([CH2:21][CH:22]([C:23]([O:25][CH3:26])=[O:24])[C:27]([O:29][CH3:30])=[O:28])=[CH:31][CH:32]=3)[C:11](=[O:13])[S:12][C:8]=2[CH:7]=1)=[O:5]

Participants

4

Reactant 1

HCID 22351066HCID 22351066, compound

Product 1

HCID 22351084HCID 22351084, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 86587333HCID 86587333, compoundSolvent

Procedure

The compound obtained in Example 37 is dissolved in a methanol/THF/dioxane solvent mixture and then a catalytic amount of palladium-on-carbon is added and the reaction is stirred at ambient temperature under a hydrogen atmosphere. The palladium-on-carbon is then filtered off and the solvents are removed by evaporation under reduced pressure. The resulting residue is taken up in isopropyl ether and stirred magnetically. The resulting precipitate is filtered off and recrystallised from methanol.

Workup

  1. filtrationThe palladium-on-carbon is then filtered off
  2. customthe solvents are removed by evaporation under reduced pressure
  3. stirringstirred magnetically
  4. filtrationThe resulting precipitate is filtered off
  5. customrecrystallised from methanol

Sources & evidence

ORD record
ord-e0bf9cfe522d4b2cbda491332d45c4d0
Source dataset
uspto-grants-2005_07
Patent number
US06919362B2

Reaction notes

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