HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-[3-(3-Aminopropyl)-4-{[(4-chlorobenzyl)oxy]methyl}thiazol-2(3H)-ylidene]-4-(trifluoromethoxy)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-(Bromomethyl)-4-chlorobenzene | HCID 69329 | — |
| Reactant | Ethyl 3-{3-[(tert-butoxycarbonyl)amino]propyl}-2-{[4-(trifluoromethoxy)phenyl]imino}-2,3-dihydrothiazol-4-carboxylate | HCID 22350979 | — |
| Product | N-[3-(3-Aminopropyl)-4-{[(4-chlorobenzyl)oxy]methyl}thiazol-2(3H)-ylidene]-4-(trifluoromethoxy)aniline | HCID 22350959 | 50.4% |
Reaction Steps
The compound (313 mg) obtained in Example 208 (2) and 4-chlorobenzyl bromide (216 mg) were treated in a similar manner to in Example 208 (3), (4) to give the title compound (152 mg) as hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06919361B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-ba7a9187841644febf840bd88838e00f |
| Source note | uspto-grants-2005_07 |