Hydrochloric Acid → N-[3-(3-Aminopropyl)-4-{[(4-chlorobenzyl)oxy]methyl}thiazol-2(3H)-ylidene]-4-(trifluoromethoxy)aniline

HRID 896618Notes

Reaction equation

HRID 896618 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][N:12]1[C:16]([C:17]([O:19][CH2:20][CH3:21])=O)=[CH:15][S:14][C:13]1=[N:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][C:30]([F:33])([F:32])[F:31])=[CH:25][CH:24]=1)=O)(C)(C)C.[Cl:34][C:35]1[CH:42]=[CH:41]C(CBr)=[CH:37][CH:36]=1.Cl>>[NH2:8][CH2:9][CH2:10][CH2:11][N:12]1[C:16]([CH2:17][O:19][CH2:20][C:21]2[CH:41]=[CH:42][C:35]([Cl:34])=[CH:36][CH:37]=2)=[CH:15][S:14][C:13]1=[N:22][C:23]1[CH:28]=[CH:27][C:26]([O:29][C:30]([F:32])([F:33])[F:31])=[CH:25][CH:24]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 693291-(Bromomethyl)-4-chlorobenzeneHCID 22350979Ethyl 3-{3-[(tert-butoxycarbonyl)amino]propyl}-2-{[4-(trifluoromethoxy)phenyl]imino}-2,3-dihydrothiazol-4-carboxylate

Product 1

HCID 22350959N-[3-(3-Aminopropyl)-4-{[(4-chlorobenzyl)oxy]methyl}thiazol-2(3H)-ylidene]-4-(trifluoromethoxy)anilineYield 50.4%

Procedure

The compound (313 mg) obtained in Example 208 (2) and 4-chlorobenzyl bromide (216 mg) were treated in a similar manner to in Example 208 (3), (4) to give the title compound (152 mg) as hydrochloride.

Sources & evidence

ORD record
ord-ba7a9187841644febf840bd88838e00f
Source dataset
uspto-grants-2005_07
Patent number
US06919361B2

Reaction notes

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