Diazomethane → Methyl 2-(4-(methylsulfonyl)phenyl)acetate

HRID 896657Notes

Reaction equation

HRID 896657 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([OH:14])=[O:13])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[N+](=[CH2:17])=[N-]>>[CH3:17][O:13][C:12](=[O:14])[CH2:11][C:8]1[CH:7]=[CH:6][C:5]([S:2]([CH3:1])(=[O:3])=[O:4])=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 9550DiazomethaneHCID 5723454-Mesylphenylacetic acid

Product 1

HCID 16640928Methyl 2-(4-(methylsulfonyl)phenyl)acetate

Procedure

(4-Methanesulfonyl-phenyl)-acetic acid was treated with an etheral solution of diazomethane until completion of esterification by TLC. The solvent was evaporated, the residue triturated in hexane/ether and filtered to afford the title compound as a white solid.

Workup

  1. customThe solvent was evaporated
  2. customthe residue triturated in hexane/ether
  3. filtrationfiltered

Sources & evidence

ORD record
ord-cf9a18ad0e5c4b3daefe5bcd84d0025d
Source dataset
uspto-grants-2005_07
Patent number
US06919353B2

Reaction notes

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