Water → HCID 22350068, compound

HRID 896662Notes

Reaction equation

HRID 896662 reaction equation
[CH3:1][S:2]([C:5]1[CH:12]=[CH:11][C:8]([CH2:9]Cl)=[CH:7][CH:6]=1)(=[O:4])=[O:3].[CH3:13][S:14]([O-:16])=[O:15].[Na+].O>CN(C=O)C>[CH3:1][S:2]([C:5]1[CH:12]=[CH:11][C:8]([CH2:9][S:14]([CH3:13])(=[O:16])=[O:15])=[CH:7][CH:6]=1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 962WaterHCID 1235301-(Chloromethyl)-4-methanesulfonylbenzeneHCID 2733271Sodium methanesulfinate

Product 1

HCID 22350068HCID 22350068, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 4-methanesulfonylbenzyl chloride (2 g, 10 mmol) in DMF (20 mL) at 21° C. was added sodium methanesulfinate (1.5 g, 15 mmol). After 18 h, the mixture is poured into cold water (100 mL), stirred for 30 min then filtered off to afford the title compound as a white solid.

Workup

  1. filtrationthen filtered off

Sources & evidence

ORD record
ord-06ad34bca03946e3ae70aabba551a837
Source dataset
uspto-grants-2005_07
Patent number
US06919353B2

Reaction notes

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