1,4-Dioxane hydrochloride → HCID 86590342, compound

HRID 896718Notes

Reaction equation

HRID 896718 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([NH:10]S(C(C)(C)C)=O)[CH3:9])=[C:4]([F:17])[CH:3]=1.[ClH:18].O1CCOCC1>CO>[Cl-:18].[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]([NH3+:10])[CH3:9])=[C:4]([F:17])[CH:3]=1

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 68454599HCID 68454599, compound

Product 1

HCID 86590342HCID 86590342, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of N-[(1R)-1-(4-bromo-2-fluorophenyl)ethyl]-2-methylpropane-2-sulfinamide (26.29 g, 81.58 mmol) in 40 mL methanol was added HCl/dioxane (4M, 40.8 mL, 0.163 mol) solution. The reaction mixture was concentrated in vacuo, and ether was added. The white solid was collected, washing with cold ether, and dried under vacuum to yield (1R)-1-(4-bromo-2-fluorophenyl)ethanaminium chloride that gave proton NMR spectra consistent with theory.

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo, and ether
  2. additionwas added
  3. customThe white solid was collected
  4. washwashing with cold ether
  5. customdried under vacuum

Sources & evidence

ORD record
ord-159f113142f34e3f8922cda7b995224f
Source dataset
uspto-grants-2005_07
Patent number
US06919343B2

Reaction notes

Loading…