1,4-Dioxane hydrochloride → HCID 86590342, compound

Participants

Reaction Steps

To a solution of N-[(1R)-1-(4-bromo-2-fluorophenyl)ethyl]-2-methylpropane-2-sulfinamide (26.29 g, 81.58 mmol) in 40 mL methanol was added HCl/dioxane (4M, 40.8 mL, 0.163 mol) solution. The reaction mixture was concentrated in vacuo, and ether was added. The white solid was collected, washing with cold ether, and dried under vacuum to yield (1R)-1-(4-bromo-2-fluorophenyl)ethanaminium chloride that gave proton NMR spectra consistent with theory.

Provenance & Evidence