HRID896936

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID79341

Piperidin-4-ol

C5H11NO

结构：CN(C(=O)OC(C)(C)C)[C@H](Cc1ccc2ccccc2c1)C(=O)O

HCID10065151

未命名化合物

HCID10847814

未命名化合物

结构：CN(C(=O)OC(C)(C)C)[C@H](Cc1ccc(F)cc1)C(=O)O

HCID53833009

未命名化合物

PRODUCTS

生成物

结构：CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccc(F)cc1)C(=O)N1CCC(O)CC1

HCID9960628

未命名化合物

PROCEDURE

实验过程

This compound was prepared as in example 1 but using 4-hydroxypiperidine, (2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-(4-fluorophenyl)propionic acid and (2R)-2-(N-tert-butoxycarbonyl-N-methylamino)-3-(2-naphthyl)propionic acid and (2E)-5-tert-butoxycarbonylamino-5-methylhex-2-enoic acid as starting materials.

WORKUP

后处理

customThis compound was prepared as in example 1

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-430e9fdc26ab4417b288b725ae030872
来源数据集: uspto-grants-2005_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06919315B1
来源说明: uspto-grants-2005_07

反应 SMILES

[OH:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.C(O[C:13]([N:15]([C@H:17]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([F:28])=[CH:24][CH:23]=1)[C:18]([OH:20])=O)[CH3:16])=[O:14])(C)(C)C.C(O[C:34]([N:36]([C@H:38]([CH2:42][C:43]1[CH:52]=[CH:51][C:50]2[C:45](=[CH:46][CH:47]=[CH:48][CH:49]=2)[CH:44]=1)C(O)=O)[CH3:37])=[O:35])(C)(C)C.C(OC([NH:60][C:61]([CH3:69])([CH3:68])[CH2:62]/[CH:63]=[CH:64]/C(O)=O)=O)(C)(C)C>>[F:28][C:25]1[CH:24]=[CH:23][C:22]([CH2:21][C@@H:17]([N:15]([CH3:16])[C:13]([C@H:38]([N:36]([CH3:37])[C:34](=[O:35])/[CH:64]=[CH:63]/[CH2:62][C:61]([NH2:60])([CH3:69])[CH3:68])[CH2:42][C:43]2[CH:52]=[CH:51][C:50]3[C:45](=[CH:46][CH:47]=[CH:48][CH:49]=3)[CH:44]=2)=[O:14])[C:18]([N:5]2[CH2:6][CH2:7][CH:2]([OH:1])[CH2:3][CH2:4]2)=[O:20])=[CH:27][CH:26]=1