反应详情

Chloroacetylchloride (60 g, 0.53M) was added with stirring to a mixture of 2-aminopyridine (50 g, 0.53M) and diisopropylethylamine (75 ml, 0.53M) in dichloromethane (500 ml) keeping the temperature below 5° C. After the reaction mixture was warmed to room temperature it was filtered and washed with water. The organic layer was dried (MgSO4) and evaporated under reduced pressure to give 72.6 g of a brown solid.

1. customthe temperature below 5° C
2. filtrationwas filtered
3. washwashed with water
4. dry with materialThe organic layer was dried (MgSO4)
5. customevaporated under reduced pressure