HCID 22347442, compound → HCID 9907963, compound

HRID 897019Notes

Reaction equation

HRID 897019 reaction equation
C(OC([NH:8][C:9]1[CH:10]=[C:11]([S:17]([NH2:20])(=[O:19])=[O:18])[CH:12]=[CH:13][C:14]=1[O:15][CH3:16])=O)(C)(C)C.C([O:28][C:29](=O)[C:30]1[C:31](=[CH:42][C:43]([Cl:46])=[CH:44][CH:45]=1)[NH:32][C:33](OC1C=CC=CC=1)=[O:34])C1C=CC=CC=1>>[NH2:8][C:9]1[CH:10]=[C:11]([S:17]([N:20]2[C:29](=[O:28])[C:30]3[C:31](=[CH:42][C:43]([Cl:46])=[CH:44][CH:45]=3)[NH:32][C:33]2=[O:34])(=[O:18])=[O:19])[CH:12]=[CH:13][C:14]=1[O:15][CH3:16]

Participants

3

Reactant 2

HCID 22347442HCID 22347442, compoundHCID 22347460HCID 22347460, compound

Product 1

HCID 9907963HCID 9907963, compoundYield 16%

Procedure

From 400 mg (1.40 mmol) of 3-t-butoxycarbonylamino-4-methoxybenzenesulfonamide and 533 mg (1.40 mmol) of 4-chloro-2-N-phenoxycarbonylanthranilic acid benzylester in a similar manner to Preparation Example 17, 86 mg (yield 16%: 4 steps) of the title compound was obtained. Property: colorless crystals, melting point: >200° C. (decomposition), PMR (δppm, DMSO-d6): 3.81 (3H, s), 7.26-7.37 (5H, m), 7.77 (1H, s), 7.90 (1H, d), 7.94 (1H, d), 11.73 (1H, s)

Sources & evidence

ORD record
ord-b862a6317f704ab0b8e4f2538a66ca89
Source dataset
uspto-grants-2005_07
Patent number
US06921766B1

Reaction notes

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