Methanol → HCID 22348438, compound

HRID 897176Notes

Reaction equation

HRID 897176 reaction equation
C(O[C:4](=[O:17])[CH2:5][C:6]1([CH2:13][N+]([O-])=O)[CH2:10][CH2:9][C:8]([CH3:12])([CH3:11])[CH2:7]1)C.[CH3:18]O>[Ni]>[CH3:12][C:8]1([CH3:11])[CH2:9][CH2:10][C:6]2([CH2:5][C:4](=[O:17])[CH2:18][CH2:13]2)[CH2:7]1

Participants

4

Reactant 2

HCID 887MethanolHCID 54521414(+/-)-(3,3-Dimethyl-1-nitromethyl-cyclopentyl)-acetic Acid Ethyl Ester

Product 1

HCID 22348438HCID 22348438, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

The ester 3 (380 mg, 1.6 mmol) and Raney Nickel (1 g) were suspended in methanol (75 mL) and shaken under a hydrogen atmosphere for 24 hours. The catalyst was removed by filtration, the filtrate concentrated to give the lactam 4 (246 mg, 94%) as a white solid.

Workup

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-b9d7611269f7434a9e222d63b4205ef7
Source dataset
uspto-grants-2005_07
Patent number
US06921835B2

Reaction notes

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