HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 22348438, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | (+/-)-(3,3-Dimethyl-1-nitromethyl-cyclopentyl)-acetic Acid Ethyl Ester | HCID 54521414 | — |
| Catalyst | Nickel | HCID 935 | — |
| Product | HCID 22348438 | HCID 22348438 | 94% |
Reaction Steps
The ester 3 (380 mg, 1.6 mmol) and Raney Nickel (1 g) were suspended in methanol (75 mL) and shaken under a hydrogen atmosphere for 24 hours. The catalyst was removed by filtration, the filtrate concentrated to give the lactam 4 (246 mg, 94%) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06921835B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-b9d7611269f7434a9e222d63b4205ef7 |
| Source note | uspto-grants-2005_07 |