3-Hydroxybenzaldehyde → HCID 10248216, compound

HRID 897201Notes

Reaction equation

HRID 897201 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[O:8][C:7](=[O:12])[CH:6]=[C:5]2[NH:13][CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1.[OH:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[CH:24]=O>>[OH:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][CH:28]=1)[CH2:24][N:17]1[CH2:18][CH2:19][CH:14]([NH:13][C:5]2[C:4]3[C:9](=[CH:10][CH:11]=[C:2]([CH3:1])[CH:3]=3)[O:8][C:7](=[O:12])[CH:6]=2)[CH2:15][CH2:16]1

Participants

3

Reactant 2

HCID 1013-HydroxybenzaldehydeHCID 22348189HCID 22348189, compound

Product 1

HCID 10248216HCID 10248216, compound

Procedure

According to Procedure A above, 6-methyl-4-(piperidin-4-ylamino)-chromen-2-one and 3-hydroxybenzaldehyde were processed to give the title compound. MS (DCI/NH3) m/z 465 [M+H]+; 1H NMR (500 MHz, DMSO) δ ppm 9.41-9.63 (m, 1H), 7.94 (m, 1H), 7.40 (m, 1H), 7.29 (m, 2H), 7.20 (m, 1H), 6.90 (m, 3H), 5.36 (m, 1H), 4.22 (m, 2H), 3.74 (m, 1H), 3.48 (m, 2H), 3.09 (m, 2H), 2.37 (m, 3H), 2.18 (m, 2H), 1.80 (m, 2H).

Sources & evidence

ORD record
ord-b04440cad66d4c0cb0ca68c0c853afda
Source dataset
uspto-grants-2005_07
Patent number
US06921821B2

Reaction notes

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