HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 897229Generated: October 30, 2026
4-(6-Methoxy-1-methyl-2-oxo-1,2-dihydro-quinolin-4-ylamino)-piperidine-1-carboxylic acid ethyl ester → 6-Methoxy-1-methyl-4-(piperidin-4-ylamino)-1H-quinolin-2-one
https://huagongshe.com/reaction/897229
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-(6-Methoxy-1-methyl-2-oxo-1,2-dihydro-quinolin-4-ylamino)-piperidine-1-carboxylic acid ethyl ester | HCID 69737330 | — |
| Solvent | Acetic Acid Mixture with Hydrobromic Acid | HCID 21893785 | — |
| Product | 6-Methoxy-1-methyl-4-(piperidin-4-ylamino)-1H-quinolin-2-one | HCID 22348014 | 145% |
Reaction Steps
4-(6-Methoxy-1-methyl-2-oxo-1,2-dihydro-quinolin-4-ylamino)-piperidine-1-carboxylic acid ethyl ester (445 mg, 1.2 mmol) was dissolved in HBr/Acetic acid (30% by weight HBr in Acetic Acid) and heated at 90° C. for 1 hr. The solvent was then evaporated to afford an orange solid (˜500 mg, 100%) which was carried onto the next step without any characterization.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06921821B2 |
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| Source dataset | uspto-grants-2005_07 |
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| ORD ID | ord-d84c8ff323c9415ab513dd35b75f04de |
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| Source note | uspto-grants-2005_07 |
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