HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 22348136, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | 6-Chloro-4-(1-ethoxycarbonyl-piperidin-4-ylamino)2-oxo-1,2-dihydro-quinoline-3-carboxylic acid methyl ester | HCID 69736958 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | HCID 22348136 | HCID 22348136 | 68.1% |
Reaction Steps
6-Chloro-4-(1-ethoxycarbonyl-piperidin-4-ylamino)2-oxo-1,2-dihydro-quinoline-3-carboxylic acid methyl ester (235 mg) was dissolved in HBr and acetic acid (1 mL, 30% by weight) and heated at 90° C. for 1 hr. The solvent was then evaporated to afford an orange solid (109 mg, 53%) which was carried onto the next step without characterization.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06921821B2 |
| Source dataset | uspto-grants-2005_07 |
| ORD ID | ord-55a72b3ba11b4077a98f0e728b604069 |
| Source note | uspto-grants-2005_07 |