反应详情

6-Chloro-4-(1-ethoxycarbonyl-piperidin-4-ylamino)2-oxo-1,2-dihydro-quinoline-3-carboxylic acid methyl ester (235 mg) was dissolved in HBr and acetic acid (1 mL, 30% by weight) and heated at 90° C. for 1 hr. The solvent was then evaporated to afford an orange solid (109 mg, 53%) which was carried onto the next step without characterization.

1. customThe solvent was then evaporated