3,4-Dimethylbenzaldehyde → HCID 10000345, compound

HRID 897249Notes

Reaction equation

HRID 897249 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([CH:18]=[CH2:19])[CH:16]=3)[O:11][C:10](=[O:20])[CH:9]=2)[CH2:3][CH2:2]1.[CH3:21][C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][C:29]=1[CH3:30])[CH:25]=O>>[CH3:21][C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][C:29]=1[CH3:30])[CH2:25][N:1]1[CH2:6][CH2:5][CH:4]([NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([CH:18]=[CH2:19])[CH:16]=3)[O:11][C:10](=[O:20])[CH:9]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 222783,4-DimethylbenzaldehydeHCID 22348214HCID 22348214, compound

Product 1

HCID 10000345HCID 10000345, compound

Procedure

4-(Piperidin-4-ylamino)-6-vinyl-chromen-2-one and 3,4-dimethylbenzaldehyde were allowed to react in a manner analogous to that previously described to give the title compound. 1H NMR (500 MHz, DMSO-D6) δ ppm 1.65 (m, 2H) 1.92 (m, 2H) 2.08 (m, 2H) 2.20 (m, 6H) 2.84 (m, 2H) 3.42 (m, 2H) 3.50 (m, 1H) 5.23 (s, 1H) 5.34 (m, 1H) 5.94 (m, 1H) 6.76 (m, 1H) 7.01 (m, 1H) 7.07 (m, 2H) 7.24 (m, 2H) 7.69 (m, 1H) 8.20 (m, 1H); MS (DCI/NH3) m/z 389 [M+H]+.

Workup

  1. customto react in a manner analogous to

Sources & evidence

ORD record
ord-457eade4d6014615ab3eae65bdb4362b
Source dataset
uspto-grants-2005_07
Patent number
US06921821B2

Reaction notes

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