Triethylamine → HCID 22346366, compound

HRID 897346Notes

Reaction equation

HRID 897346 reaction equation
[Cl-].[CH:2]([S:4]([NH:7][CH2:8][CH2:9][NH3+:10])(=[O:6])=[O:5])=[CH2:3].C(N(CC)CC)C>CO>[S:4]1(=[O:6])(=[O:5])[CH2:2][CH2:3][NH:10][CH2:9][CH2:8][NH:7]1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 22346282HCID 22346282, compound

Product 1

HCID 22346366HCID 22346366, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 2-[(vinylsulfonyl)amino]ethanaminium chloride (1.17 g, 6.24 mmol) in methanol (50 ml) at room temperature, was treated with triethylamine (0.87 mL, 6.24 mmol) and then stirred for 28 hr. Silica gel (10 g) was added to the solution. The solvent was evaporated in vacuo and the remaining silica gel was applied to a column of silica gel and chromatographed eluting with 4% ammonium hydroxide in acetonitrile to afford the title compound as an oil.

Workup

  1. additionSilica gel (10 g) was added to the solution
  2. customThe solvent was evaporated in vacuo
  3. customchromatographed
  4. washeluting with 4% ammonium hydroxide in acetonitrile

Sources & evidence

ORD record
ord-e96e35035fe341f49673a2d59c884854
Source dataset
uspto-grants-2005_07
Patent number
US06921759B2

Reaction notes

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