N-Methyl-1,3-propanediamine → 2-Methyl-[1,2,6]thiadiazinane 1,1-dioxide

Participants

Reaction Steps

To a solution of N-methyl-1,3-diaminopropane (37.6 mL, 312 mmol) and sulfamide (10.0 g, 104 mmol) were heated at reflux for 16 hr. The solvent was evaporated in vacuo and the residue was purified by chromatography (SiO2, EtOAc/CH2Cl2: 1:1) to afford the title compound as an oil.

Provenance & Evidence