N-Methyl-1,3-propanediamine → 2-Methyl-[1,2,6]thiadiazinane 1,1-dioxide

HRID 897351Notes

Reaction equation

HRID 897351 reaction equation
[CH3:1][NH:2][CH2:3][CH2:4][CH2:5][NH2:6].[S:7](N)(N)(=[O:9])=[O:8]>>[CH3:1][N:2]1[CH2:3][CH2:4][CH2:5][NH:6][S:7]1(=[O:9])=[O:8]

Participants

3

Reactant 2

HCID 80511N-Methyl-1,3-propanediamineHCID 82267Sulfamide

Product 1

HCID 100805602-Methyl-[1,2,6]thiadiazinane 1,1-dioxide

Procedure

To a solution of N-methyl-1,3-diaminopropane (37.6 mL, 312 mmol) and sulfamide (10.0 g, 104 mmol) were heated at reflux for 16 hr. The solvent was evaporated in vacuo and the residue was purified by chromatography (SiO2, EtOAc/CH2Cl2: 1:1) to afford the title compound as an oil.

Workup

  1. temperatureat reflux for 16 hr
  2. customThe solvent was evaporated in vacuo
  3. customthe residue was purified by chromatography (SiO2, EtOAc/CH2Cl2: 1:1)

Sources & evidence

ORD record
ord-7b2272a67b394ea7b4de3fc75b32eafd
Source dataset
uspto-grants-2005_07
Patent number
US06921759B2

Reaction notes

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